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We have good news for anyone that’s skipped a laundry day: As far as health is concerned, there is no issue with wearing the same pair of underpants two days in a row, says Greatist expert J. But before you wear your “Monday” pair on Tuesday, there are two important exceptions: If you have any skin scratches, sores, or rashes, don’t stretch your mileage on your underwear, or you could end up with an infection.